Ellen Moon1

F, #63541, b. December 1860, d. 1926

Family: Joseph E. Houghton b. Jul 1859, d. 1934

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthDec, 1860NY, USA, age 39 in 1900 census; age 49 in 1910 census; age 59 in 1920 census; GS: 18611
Marriagecirca 1891mar 9 years in 1900 census; mar 18 y in 1910 census1
1900 Census1900Hadley, Saratoga Co., NY, USA, age 41, farmer; 7 children born and living2
1910 Census1910Hadley, Saratoga Co., NY, USA, age 50, farmer; next door to brother Charles3
1920 Census1920Hadley, Saratoga Co., NY, USA, age 60, farmer4
Death1926Hadley, NY, USA
BurialHadley Hill Cemetery, Saratoga Co., NY, USA1
ParentsDparents born in NY
Pedigree

Citations

  1. [S654] Electronic Web Site, , Town of Hadley Cemeteries, Saratoga Co., NY, Saratoga NYGenWeb.
  2. [S1230] 1900 U.S. Federal Census , Hadley, Saratoga Co., New York; Roll: T623 1158; Enumeration District: 115; Sheet 4A; line 31, dwl 83-83.
  3. [S1231] 1910 U.S. Federal Census , Hadley, Saratoga, New York; Roll: T624_1076; Page: 6B; Enumeration District: 107; line 76, dwl 121-124.
  4. [S1232] 1920 U.S. Federal Census , Hadley, Saratoga, New York; Roll: T625_1261; Page: 5B; Enumeration District: 111; line 86, dwl 114-115.
  5. [S1233] 1930 U.S. Federal Census , Hadley, Saratoga, New York; Roll: 1643; Page: 7A; Enumeration District: 17; Image: 543.0; FHL microfilm: 2341377; line 38, dwl 163.

Ina Houghton1

F, #63542, b. March 1897

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthMar, 1897NY, USA, age 3 in 1900 census2
Pedigree

Citations

  1. [S1230] 1900 U.S. Federal Census , Hadley, Saratoga Co., New York; Roll: T623 1158; Enumeration District: 115; Sheet 4A; line 31, dwl 83-83.
  2. [S654] Electronic Web Site, , Town of Hadley Cemeteries, Saratoga Co., NY, Saratoga NYGenWeb.

Emory Houghton1

M, #63543

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
Birth1
Pedigree

Citations

  1. [S654] Electronic Web Site, , Town of Hadley Cemeteries, Saratoga Co., NY, Saratoga NYGenWeb.

Blanche A. Houghton1,2

F, #63544, b. February 1894

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
BirthFeb, 1894NY, USA, age 6 in 1900 census; age 16 in 1910 census1,2
Pedigree

Citations

  1. [S654] Electronic Web Site, , Town of Hadley Cemeteries, Saratoga Co., NY, Saratoga NYGenWeb.
  2. [S1230] 1900 U.S. Federal Census , Hadley, Saratoga Co., New York; Roll: T623 1158; Enumeration District: 115; Sheet 4A; line 31, dwl 83-83.

Dr. Jan Marie Laws M. D.1,2

F, #63545, b. circa 1950

Family: Dr. Raymond Carl Houghton Jr, Ph.D. b. 26 May 1947, d. 30 May 2007

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
Birthcirca 1950
MarriageSep 22, 19731,2
Living2007Delmar, NY, USA3
OccupationDr. Houghton is the Academic Director of Interventional Cardiology and the Director of the Women's Healthy Heart Initiative Program. She is an active interventional cardiologist and researcher in The Heart Institute at Albany Medical Center. As Professor of Medicine at Albany Medical College, she trains other doctors in the practice of cardiology.

Dr. Houghton graduated from Virginia Polytechnic Institute Summa Cum Laude in Engineering. She attended graduate school at Johns Hopkins University Medical School in Biomedical Engineering, and then graduated from medical school at University of Maryland Medical School with honors. She was elected to the national engineering honor society, Tau Beta Pi, and the national medicine honor society, Alpha Omega Alpha. A residency in internal medicine at the University of Maryland Hospital followed by a fellowship in cardiology at the University of North Carolina Hospital completed her postgraduate medical training.

Dr. Houghton is highly skilled in the performance of diagnostic cardiac catheterization and interventional procedures such as balloon angioplasty, coronary artery stenting, rotational atherectomy, and intravascular ultrasound. Her clinical interests include the diagnosis and treatment of coronary artery disease, coronary artery spasm, complicated hypertension, and the practice of critical care cardiology. Dr. Houghton has a special interest in women's health and is a member of The NYS Governor's Advisory Board on Women & Heart Disease.

Dr. Houghton has received many research grants from various sources including the American Heart Association, the National Institutes of Health, and pharmaceutical companies. The National Heart, Lung, and Blood Institute awarded her 1.5 million dollars to study racial and gender differences in the coronary circulation and to investigate microcirculatory spasm. She is the author of more than 35 scientific publications and annually presents research papers at major cardiology and hypertension meetings including those sponsored by the American Heart Association, the American College of Cardiology, and the American Society of Hypertension.

Dr. Houghton is board certified by the American Board of Internal Medicine in Internal Medicine, Cardiovascular Diseases, Critical Care Medicine, and Interventional Cardiology. The American Society of Hypertension recently named her Specialist in Clinical Hypertension.

Albany Medical Center
43 New Scotland Avenue
Albany, New York 122084
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://www.cyhaus.com/mikenapril/program.htm
  2. [S415] E-mail from Raymond C. Houghton, Jr., Apr 8, 2004.
  3. [S93] Newspaper Obituary, http://www.alumni.norwich.edu/s/758/index.aspx
  4. [S654] Electronic Web Site, , http://heart.amc.edu/houghton.htm

Dr. Raymond Carl Houghton Jr, Ph.D.1

M, #63546, b. 26 May 1947, d. 30 May 2007

Family: Dr. Jan Marie Laws M. D. b. c 1950

Biography

Corresponded with authorY
A Contributor to Houghton Surname ProjectY
BirthMay 26, 1947Greenfield, MA, USA3
Research
Mil. Serv.between Oct 13, 1971 and Oct 12, 1972Vietnam, He served his country in the US Army as a second lieutenant (101st Airborne) field artillery officer in the Vietnam War from October 13, 1971 to October 12, 1972. He was decorated with the National Defense Service Medal, Vietnam Campaign Medal, Vietnam Service Medal, Air Medal, Army Commendation Medal with "V," Bronze Star and Purple Heart.4
MarriageSep 22, 19732,3
Authorbetween 1981 and 1982[ 1 ] Houghton, Raymond C.      Features of software development tools / Raymond C. Houghton, Jr.      Washington, D.C. : U.S Dept. of Commerce, National Bureau of Standards : For sale by the Supt. of Docs., U.S. G.P.O., 1981.
Location: US Government Documents      Call Number: C 13.10:500-74
[ 2 ] Houghton, Raymond C.      Proceedings of the NBS/IEEE/ACM Software Tool Fair : held in conjunction with the 5th International Conference on Software Engineering in San Diego, CA, March 10-12, 1981 / editor Raymond C. Houghton, Jr; sponsored by National Bureau of Standards and IE      Washington, D.C. : U.S. Dept. of Commerce, National Bureau of Standards : For sale by the Supt. of Docs., U.S. G.P.O., 1981.
Location: US Government Documents      Call Number: C 13.10:500-80      
[ 3 ] Houghton, Raymond C.      Software development tools / Raymond C. Houghton, Jr.      Washington, D.C. : U.S. Dept. of Commerce, National Bureau of Standards : For sale by the Supt. of Docs., U.S. G.P.O., 1982.
Location: US Government Documents      Call Number: C 13.10:500-881      
Graduation1991Duke University, Durham, NC, USA, Ph.D., computer science; Dissertation: Performance Evaluation of Task Graphs on Parallel Architectures
AddressApr 8, 200485 Carstead Drive, Slingerslands, NY, USA, cyhaus@msn.com


Cyber Haus
159 Delaware Ave, #145
Delmar, NY 12054
DNA ProjectApr 11, 2004Test: 12-YDNA
DNA ProjectApr 23, 2004John Houghton of Lancaster MA via son Robert; permission for both data and name
DeathMay 30, 2007St. Peter's Hospice Inn, Albany, Albany Co., NY, USA4,5
ObituaryMay 31, 2007Pittsfield, MA, USA, Berkshire Eagle, The (Pittsfield, MA) - May 31, 2007
Deceased Name: Raymond Houghton Jr., 60, PHS graduate
Thursday, May 31 PITTSFIELD — Raymond Carl Houghton Jr., 60, of Delmar, N.Y., formerly of Pittsfield, died Wednesday at St. Peter's Hospice Inn in Albany, N.Y.
Born in Greenfield on May 26, 1947, he lived throughout New England in his early years and was a graduate of Pittsfield High School in 1965 and Norwich University in 1969 with a bachelor's degree mathematics. He served as second lieutenant with the 101st Airborne Field Artillery during the Vietnam War from Oct. 13, 1971, to Oct. 12, 1972. He was decorated with the National Defense Service Medal, Vietnam Campaign Medal, Vietnam Service Medal, Air Medal, Army Commendation Medal, Bronze Star and Purple Heart.
Upon discharge he received a master's degree in computer science from George Washington University in 1975 and a master's degree in electrical engineering from Johns Hopkins in 1980 while working as an analyst and project leader for the National Security Agency and National Bureau of Standards in Maryland. He completed his doctorate in computer science at Duke University in Durham, N.C., in 1991. He was associate professor at Augusta (Ga.) State University in the mid-1980s to early 1990s. He served as adjunct lecturer at Skidmore College in Saratoga Springs, N.Y. In 1995 he opened Cyberhaus, a computer learning center in Delmar, N.Y. Previously, he worked as a programmer for General Electric in Pittsfield. He wrote several award-winning Revolutionary War travel books and hosted tours and talks on the subject. In 2005 he became town historian for the Town of Bethlehem, N.Y., and was a columnist for "Our Towne" newsletter. He was a featured author of "In the Beginning: Tecollections of Software Pioneers."
He was also a People to People Ambassador to China, Vietnam and Cambodia.He and his wife, the former Jan Laws, were married Sept. 22, 1973. Besides his wife, he leaves a son, Raymond James Houghton of Philadelphia; two daughters, April Houghton Blakeslee of Pittsfield, N.H., and Amy Houghton of Kalamazoo, Mich; two brothers, Jerry Houghton of Billerica and Scott Houghton of Simsbury, Conn; a sister, Theresa Houghton of Las Vegas; and a grandson.

FUNERAL NOTICE — The funeral for Raymond Carl Houghton Jr., who died Wednesday, May 30, 2007, will be held at 10 a.m. on Saturday at First Lutheran Church, 181 Western Ave. (Between N. Lake Ave. and Quail St.), Albany, N.Y. Burial will be at 1 p.m. on Monday at Massachusetts National Cemetery in Bourne. Relatives and friends are invited to call tomorrow from 4 to 8 p.m. at APPLEBEE FUNERAL HOME, 403 Kenwood Ave., Delmar, N.Y. In lieu of flowers, memorial contributions may be made to the Delmar Rescue Squad, 145 Adams St., Delmar, NY 12054. During his time in New York he began to pursue his interest in history, specifically the Revolutionary War. His recollections included creating possibly the first e-mail in the 1960s coming about from a complicated scheme to talk to a girlfriend at Colby Junior College by taking advantage of a remote connection hosted by Dartmouth College. He made arguably the world's finest sugar-free sweet potato pie. He also leaves a son-in-law, Michael Blakeslee, and a grandson, Westley James Blakeslee; as well as numerous nephews and nieces. He had honors from the Department of Commerce, was consistently listed in Who's Who in America, and was a Bethlehem Middle School mentor. He built and maintained several community Web sites, including Feestelijik Bethlehem and sat on a committee that brought about the Bethlehem Veteran's Memorial.

(c) 2007 The Berkshire Eagle. All rights reserved. Reproduced with the permission of Media NewsGroup, Inc. by NewsBank, Inc.5
BurialJun 4, 2007Massachusetts National Cemetery, Bourne, Barnstable Co., MA, USA
ResearchWho's Who in America(R) (Marquis(TM)). 51st edition, 1997. New Providence, NJ: Marquis Who's Who, 1996. (WhoAm 51)
Who's Who in America(R) (Marquis(TM)). 52nd edition, 1998. New Providence, NJ: Marquis Who's Who, 1997. (WhoAm 52)
Who's Who in America(R) (Marquis(TM)). 53rd edition, 1999. New Providence, NJ: Marquis Who's Who, 1998. (WhoAm 53)
Who's Who in America(R) (Marquis(TM)). 54th edition, 2000. New Providence, NJ: Marquis Who's Who, 1999. (WhoAm 54)
Who's Who in America(R) (Marquis(TM)). 55th edition, 2001. New Providence, NJ: Marquis Who's Who, 2000. (WhoAm 55)
Who's Who in America(R) (Marquis(TM)). 56th edition, 2002. New Providence, NJ: Marquis Who's Who, 2001. (WhoAm 56)
Who's Who in America(R) (Marquis(TM)). 57th edition, 2003. New Providence, NJ: Marquis Who's Who, 2002. (WhoAm 57)
Who's Who in the Media and Communications(R) (Marquis(TM)). 1st edition, 1998-1999. New Providence, NJ: Marquis Who's Who, 1997. (WhoMedi)
Who's Who in Science and Engineering. Second edition, 1994-1995. New Providence, NJ: Marquis Who's Who, 1994. (WhoScEn 2)
Who's Who in the World(R) (Marquis(TM)). 14th edition, 1997. New Providence, NJ: Marquis Who's Who, 1996. (WhoWor 14)
Who's Who in the World(R) (Marquis(TM)). 17th edition, 2000. New Providence, NJ: Marquis Who's Who, 1999. (WhoWor 17)
Who's Who in America(R) (Marquis(TM)). 58th edition, 2004. New Providence, NJ: Marquis Who's Who, 2003. (WhoAm 58)
Who's Who in the World(R) (Marquis(TM)). 21st edition, 2004. New Providence, NJ: Marquis Who's Who, 2003. (WhoWor 21)6
BiographyDr. Ray Houghton is a former college professor, government computer scientist, and General Electric programmer. He has been teaching computers for over 10 years and has been on the Internet for over 20 years. He has honors from the Department of Commerce, the IEEE Computer Society and is listed in Who’s Who in American Education. He received the PhD in computer science at Duke University. More recently, he authored several history-based travel books -- see www.revolutionaryday.com. The books evolved from this web site. My Route 7 book is dedicated "In memory of Daniel Houghton and William French, who gave their lives for Vermont independence at the Westminster Massacre, March 13, 1775." The book includes a discussion of the birth of the State of Vermont and Daniel's role in the birth.7
ContributnDNA to the Houghton DNA project
Pedigree

Citations

  1. [S654] Electronic Web Site, , Columbia University Libraries Online Catalog: Houghton Surname search, Nov. 2003.
  2. [S654] Electronic Web Site, , http://www.cyhaus.com/mikenapril/program.htm
  3. [S415] E-mail from Raymond C. Houghton, Jr., Apr 8, 2004.
  4. [S93] Newspaper Obituary, http://www.alumni.norwich.edu/s/758/index.aspx
  5. [S654] Electronic Web Site, , http://www.genealogybank.com/gbnk/obituaries; Houghton Surname.
  6. [S882] Ancestry.Com, online www.ancestry.com, Biography and Genealogy Master Index (BGMI): Houghton Surname.
  7. [S654] Electronic Web Site, , http://www.cyhaus.com

Dr. April Monica Houghton1,2

F, #63547, b. 16 April 1976

Family: Michael David Blakeslee

  • Marriage*: Dr. April Monica Houghton married Michael David Blakeslee on Jun 10, 2000 Marsh Chapel, Boston University.1

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthApr 16, 1976Baltimore, Baltimore Co., MD, USA3
MarriageJun 10, 2000Marsh Chapel, Boston University1
AddressSep, 200214 Temple Street, Apt. E407, Framingham, MA, USA, aprilh@bu.edu; mdblakes@bu.edu
Living2007Pittsfield, NH, USA
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://www.cyhaus.com/mikenapril/program.htm
  2. [S93] Newspaper Obituary, http://www.alumni.norwich.edu/s/758/index.aspx
  3. [S415] E-mail from Raymond C. Houghton, Jr., Apr 8, 2004.

Michael David Blakeslee1

M, #63548

Family: Dr. April Monica Houghton b. 16 Apr 1976

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
MarriageJun 10, 2000Marsh Chapel, Boston University1
Living2007Pittsfield, NH, USA
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://www.cyhaus.com/mikenapril/program.htm
  2. [S93] Newspaper Obituary, http://www.alumni.norwich.edu/s/758/index.aspx

Amy Houghton1

F, #63549, b. 25 April 1983

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthApr 25, 1983Baltimore, Baltimore Co., MD, USA2
Living2007Kalamazoo, MI, USA3
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://www.cyhaus.com/mikenapril/program.htm
  2. [S415] E-mail from Raymond C. Houghton, Jr., Apr 8, 2004.
  3. [S93] Newspaper Obituary, http://www.alumni.norwich.edu/s/758/index.aspx

Dr. John E. Houghton Ph.D.1

M, #63550

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
Graduation1986Texas A&M University, College Station, Brazos Co., TX, USA, Ph.D. Biochemistry
AuthorBuck, G. W., L. Jiang, Z. Guo and J. E. Houghton Pseudomonas putida Encodes a b-ketoadipate Specific Transport (PcaT) that is Expressed from Within a pcaFTBDC Operon. Manuscript submitted to Journal of Bacteriology

Sumner, E. R., A. Shanmuganathan, T. C. Sideri, S. A. Willetts, J. E. Houghton and S. V. Avery (2005) Oxidative Protein Damage Causes Chromium Toxicity in Yeast Microbiology. (Accepted for Publication)

Shanmuganathan, A., S.V. Avery, S.A Willetts and J.E. Houghton (2004) Copper-induced Oxidative Stress in Saccharomyces cerevisiae Targets Enzymes of the Glycolytic Pathway FEBS Letters. 556: 253-2259.

Sumner, E. R., A. M.Avery, A Shanmugnathan, J. E. Houghton, R. A Robbins, and S. V. Avery (2003) Cell Cycle and Age-Dependent Activation of Sod1p Drives the Formation of Stress Resistant Cell Subpopulations within Clonal Cultures. Molecular Microbiology. 32: 253-264.

Herman, H. H., Weimin, L., Petrecca, Herman, T. M., Christopher Bates, C., Simmons, R. and J. E. Houghton. (2001) Centrifugal Bioreactors and their Application in Wastewater Remediation Remediation 11: 15 - 33.

Guo, Z. and Houghton, J. E. (1999) PcaR-mediated activation and Repression of pca genes from Pseudomonas putida are Propagated by Binding to Both the ?35 and the ?10 Promoter Elements. Molecular Microbiology. 32: 253-265.

Hebert, M. D. and Houghton, J. E. (1997) Regulation of Ornithine Utilization in Pseudomonas aeruginosa(PAO1) is Mediated by a Transcriptional Regulator, OruR. Journal of Bacteriol. 179: 7834-7842.

Houghton, J.E., Brown, T.M., Appel, A.J., Hughes E.J. and L.N. Ornston. (1995) Discontinuities in the Evolution of Pseudomonas putida cat Genes. Journal of Bacteriol. 177: 401-412.

Kwon, D-H., Lu, C-D., Walthall, D. A., Brown, T. M., Houghton, J. E. and Abdelal, A. T. (1994) Structure and Regulation of the carAB Operon in Pseudomonas aeruginosa and Pseudomonas stutzeri: No Untranslated Region Exists. Journal of Bacteriol. 176: 2532-2542.

Romero-Steiner, S., Parales, R. E., Harwood, C. S., Houghton, J. E. (1994) Characterization of the pcaR Regulatory Gene from Pseudomonas putida, which is required for the Complete Degradation of p-Hydroxybenzoate. Journal of Bacteriol. 176: 5771-5779.
Duplicate
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://www.gsu.edu/~wwwbio/depart/faculty/houghton.htm

Dr. Janet Anne Houghton Ph.D.1,2

F, #63551, b. 21 May 1952, d. 5 October 2017

Family 1: Dr. Peter James Houghton Ph.D. b. 1949

  • Marriage*: Dr. Janet Anne Houghton Ph.D. married Dr. Peter James Houghton Ph.D.
  • Divorce*: Dr. Janet Anne Houghton Ph.D. and Dr. Peter James Houghton Ph.D. were divorced.

Family 2: Robert Alan Klaus b. c 1952

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthMay 21, 1952England
ResidenceMemphis, TN
Somerville, TN
Education19701970-1973 University of Bradford, England; BPh (Honors) in Experimental Pharmacology
1973-1974 Membership of the Pharmaceutical Society of Great Britain
1974-1977 Institute of Cancer Research, Sutton, Surrey, England; Ph.D. in Biochemistry, University of London
1977-1980 Research Fellow, Department of Pharmacology, St. Jude Children's Research Hospital (SJCRH), Memphis, TN
1980-1982 Research Associate, Department of Pharmacology, SJCRH, Memphis,
1982-1985 Assistant Member, Department of Pharmacology, SJCRH, Memphis, TN
1985-1990 Associate Member, Department of Pharmacology, SJCRH, Memphis, TN
1990-1999 Member, Department of Pharmacology, SJCRH, Memphis, TN
1999-2006 Member, Department of Hematology-Oncology, SJCRH, Memphis, TN
2006-2010 Senior Leader, Associate Director for the Lerner Research Institute, Case Comprehensive Cancer Center, Cleveland, OH
2006-2011 Chair, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
2006-present Staff, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
Graduation1977University of Longon, London, England, PhD
Marriage
Occupationbetween 1990 and 1999Janet A. Houghton, Ph.D.

Research Interests

My research goals are to elucidate the role of death receptors of the TNF receptor superfamily, and their signaling pathways, in drug-induced apoptosis in solid tumors. Our interests are in epithelial cancers, particularly colorectal carcinomas, and in pediatric solid tumors. The current focus of the research is: 1) to determine the role of Fas and the Fas signaling pathway and their modulation in drug-induced apoptosis of epithelial cancers, and 2) to elucidate the TRAIL signaling pathway in certain types of solid tumors, and to explore the role of the cytotoxic ligand TRAIL as an agent that can target solid tumors either alone or in combination with chemotherapeutic agents.

TRAIL (Apo-2L) and FasL (CD95L, Apo-1L) share the highest homology among the TNF family members and the ability to induce apoptosis. The TNF receptor superfamily consists of at least fourteen molecularly defined ligand-receptor pairs. The cell surface receptor Fas, and its ligand, FasL, are known regulators of apoptosis in cells of the immune system. By blocking Fas/FasL interactions in human colon carcinoma cells, thymineless death was shown to be regulated via Fas and its signaling pathway. FasL was transcriptionally activated by NF-B and AP-1 downstream of DNA damage, and Fas was upregulated by the cytokine IFN- thereby sensitizing cells to treatment with 5-fluorouracil combined with leucovorin in a Fas-dependent manner. The laboratory continues to explore mechanisms to regulate Fas-dependent, drug-induced apoptosis in epithelial cancers, and to sensitize cells to cancer therapy. These include: 1) the role of cytokines and their mechanism(s) of action in modulation of of Fas-mediated and drug-induced apoptosis in cell lines, xenograft models, and in clinical trials in patients with colon cancer, and 2) exploration the role of inhibitors of matrix metalloproteinases that prevent cleavage of FasL from the cell surface, in sensitization of cells to Fas-mediated apoptosis and as a potential therapeutic approach .

Considerably less is known concerning the biologic function of TRAIL in the regulation of apoptosis in cells and tissues. Normal cells are in general TRAIL-resistant, whereas tumor cell lines of diverse origin are sensitive to TRAIL. There are four TRAIL receptors: DR4 and DR5, like Fas, contain a cytoplasmic death domain, while DcR1 and DcR2, decoy receptors, bind the ligand with comparable affinity but cannot transmit an apoptotic signal. Pediatric rhabdomyosarcma (RMS) cell lines are resistant to Fas- but highly sensitive to TRAIL-mediated apoptosis. They all express high levels of DR5, but vary in their levels of expression of procaspase-8, procaspase-10 and c-FLIP. The roles of DISC formation, caspase-8 or caspase-10 as initiator caspases upstream or downstream of the mitochondria, delineation of the TRAIL signaling pathway, and factors that determine TRAIL sensitivity or resistance will be determined. Future goals involve testing of specific hypotheses in xenograft models in SCID mice.

Selected Publications

Petak I, Tillman DM, Houghton JA. P53-dependence of Fas induction amd acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines. Clin Cancer Res, November, 2000.

Petak I, Douglas L, Tillman DM, Vernes R, Houghton JA. Rhabdomyosarcoma cell lines are resistant to Fas- and highly sensitive to TRAIL-induced apoptosis. Clin Cancer Res, October, 2000.

Petak I, Tillman DM, Harwood FG, Houghton JA. Fas -dependent and -independent mechanisms of cell death following DNA damage in human colon carcinoma cells. Cancer Res 60:2643-2650, 2000.

Harwood FG, Kasibhatla S, Petak I, Vernes R, Green DR, Houghton JA. Regulation of FasL by NF-B and AP-1 in Fas-dependent thymineless death of colon carcinoma cells. J Biol Chem, 275:10023-10029, 2000.

Houghton JA. Apoptosis and drug response. Curr Opin Oncol 11:475-481, 1999.

Tillman DM, Petak I, Houghton JA. A Fas-dependent component in 5-fluorouracil/ leucovorin-induced cytotoxicity in colon carcinoma cells. Clin Cancer Res 5:425-430, 1999.

Houghton JA, Ebanks R, Harwood FG, Tillman DM. Inhibition of apoptosis following thymineless stress is conferred by oncogenic K-ras in colon carcinoma cells. Clin Cancer Res 4:2841-2848, 1998.

Tillman DM, Harwood FG, Gibson AA, Houghton JA. Expression of genes that regulate Fas signaling and Fas-mediated apoptosis in colon carcinoma cells. Cell Death Diff. 5:450-457, 1998.

Houghton JA, Harwood FG, Gibson AA, Tillman DM. The Fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clin Cancer Res 3:2205-2209, 1997.

Houghton JA, Harwood FG, Tillman DM. Thymineless death in colon carcinoma cells is mediated via Fas signaling. Proc. Natl. Acad. Sci. USA 94:8144-8149, 1997.

Hare CB, Elion GB, Houghton PJ, Houghton JA, Keir S, Marcelli SL, Bigner DD, Friedman HS: Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyl-oxy-camptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol 39:187-91, 1997

Houghton JA, Harwood FG, Gibson AA, Tillman DM: The Fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clin Cancer Res 3: 2205-9, 1997

Houghton JA, Harwood FG, Tillman DM: Thymineless death in colon carcinoma cells is mediated via Fas signaling. Proc Natl Acad Sci USA 94:8144-9, 1997

Thompson J, Zamboni WC, Cheshire PJ, Lutz L, Luo X, Li Y, Houghton JA, Stewart CF, Houghton PJ: Efficacy of systemic administration of irinotecan against neuroblastoma xenografts. Clin Cancer Res 3:423-31, 1997

Thompson J, Zamboni WC, Cheshire PJ, Richmond L, Luo X, Houghton JA, Stewart CF, Houghton PJ: Efficacy of oral irinotecan against neuroblastoma xenografts. Anticancer Drugs 8:313-22, 1997

Harwood FG, Frazier MW, Krajewski S, Reed JC, Houghton JA: Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells. Oncogene 12:2057-67, 1996

Houghton JA, Cheshire PJ, Hallman JD II, Lutz L, Luo X, Li Y, Houghton PJ: Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma. Clin Cancer Res 2:107-18, 1996

Houghton PJ, Houghton JA: Antitumor diarylsulfonylureas: Novel agents with unfulfilled promise. Invest New Drugs 14:271-80, 1996

Houghton PJ, Stewart CF, Zamboni WC, Thompson J, Luo X, Danks MK, Houghton JA: Schedule-dependent efficacy of camptothecins in models of human cancer. Ann N Y Acad Sci 803:188-201, 1996

Merriman RL, Hertel LW, Schultz RM, Houghton PJ, Houghton JA, Rutherford PG, Tanzer LR, Boder GB, Grindey GB: Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models. Invest New Drugs 14:243-7, 1996

Thulasi R, Dias P, Houghton PJ, Houghton JA: alpha 2a-interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: Correlation with down- regulation of the insulin-like growth factor type 1 receptor. Cell Growth Differ 7:531-41, 19961
Author1993Title:      Preclinical and clinical modulation of anticancer drugs / authors, Kenneth D. Tew, Peter J. Houghton, Janet A. Houghton.
Physical Description:      viii, 364 p. : ill; 26 cm.
Series:      Pharmacology & toxicology (Boca Raton, Fla.)
Publisher/ Date:      Boca Raton : CRC Press, 1993.

Authors ? Peter J Houghton
Testing of New Agents in Childhood Cancer Preclinical Models: Meeting ...
Peter J. Houghton, Peter C. Adamson, Susan Blaney, Howard A. Fine, Richard Gorlick, Michelle Haber, Lee Helman, Steve Hirschfeld, Melinda G. Hollingshead, Mark A. ...
http://www.nant.org/documents/mponbl2002houghton.pdf

Relationship Between Topotecan Systemic Exposure and Tumor Response in ...
Catherine Poquette, Janet A. Houghton, Peter J. Houghton ... Correspondence to: Peter J. Houghton, Ph.D., Department of Molecular Phar ...
http://jnci.oxfordjournals.org/cgi/reprint/jnci;90/7/505.pdf

Molecular Pharmacology
Members • Mary-Ann Bjornsti, PhD; Peter J. Houghton, PhD ... The program includes researchers from the United. States and Australia. Peter J. Houghton, PhD ...
https://www.stjude.org/SJFile/3-10_mol_pharmacology_sr2007_0...

Microsoft PowerPoint - phoughton
Dr. Peter J. Houghton received his B.Ph. degree with ... Peter J. Houghton, PhD. Chairman of Molecular Pharmacology. Co-Leader, Solid Malignancies Program ...
http://pharmsci.buffalo.edu/seminar/phoughton.pdf

Saturday, April 16, 2005
to Phase I Trials, Peter J. Houghton, Chairperson, Ballroom E, Anaheim ... Judah J. Folkman, and Peter J. Houghton, Co-Chairpersons, California Pavilion A...
http://www.aacr.org/PDF_files/2005am/2005_Final_Program/2005...

Schedule-dependent Activity of Temozolomide plus CPT-11 against a Human ...
Vikas J. Patel, Gertrude B. Elion, 2. Peter J. Houghton, Stephen Keir, Anthony E. Pegg, Stewart P. Johnson, M. Eileen Dolan, Darell D. Bigner, and. Henry S. ...
http://www.brainlife.org/reprint/patel_200010.pdf

2005 Program Committee
Susan D. Desmond-Hellmann. Charis Eng. Olivera J. Finn. Tona M. Gilmer. Peter J. Houghton. David J. Hunter. Scott H. Kaufmann. Thomas W. Kensler. Lawrence J. Marnett ...
http://www.aacr.org/PDF_files/2005am/FebProgram/2005_AM_Comm...

Cytotoxic Stilbenes from Cajanus cajan (L.) Millsp. Leaves
Joseph S Ashidi, Peter J Houghton and Peter J Hylands. Pharmacognosy Research Laboratories, Pharmaceutical Sciences Research Division, King's ...
http://www.phcog.org/AnnualMtg/2006/papers/P_202.pdf3
NaturalizationApr 30, 1993
Divorce
Marriage
AddressSep, 2002Memphis, TN, USA, St. Jude Children's Research Hospital.
501 St. Jude Place, Memphis, TN 381051
DeathOct 5, 2017Hudson, OH, USA
ObituaryOct 9, 2017DR. JANET A. HOUGHTON
passed away at age 65 on October 5, 2017, after a courageous battle with appendiceal cancer. Dr. Houghton devoted her own life's work to cancer research, making a name for herself as a leading cancer biologist who was world-renowned for her efforts towards the development of new and innovative treatment therapies to help others fighting the disease that eventually took her life. Dr. Houghton's highly distinguished career began in the United Kingdom where she obtained a Ph.D. from the University of London in 1977 at the age of 25. Later that year she came to the United States, where she developed an independent career spanning 29 years at St. Jude Children's Research Hospital in Memphis, Tennessee. In 2006 she moved to the Cleveland Clinic as the Chair of the Department of Cancer Biology at the Lerner Research Institute and the Betsy B. DeWindt Endowed Chair for Cancer Research, where she focused on adult colorectal cancer. Her last professional appointment was the Distinguished Fellow and Emil Hess Endowed Chair of Cancer Biology in the Division of Drug Discovery at Southern Research Institute in Birmingham, Alabama. Her research and collaboration with other cancer biologists at St. Jude's resulted in the development of one of the leading forms of colorectal cancer treatment still used by thousands of patients each year. Her work has also been the focus of over 145 scientific peer-reviewed publications and ten book chapters, She served on several National Institutes of Health Study Sections for her expertise in her field, and she hailed as Senior Editor for the international journal Cancer Research for over 12 years. Dr. Houghton grew up in the small tranquil village of South Witham in rural Lincolnshire England among haystacks and herds of sheep, near Nottingham, of Robin Hood fame and Sir Isaac Newton's cottage. Her older brother, Robert, a roof-thatcher and bass-guitarist, introduced her to the music of legendary blues artists like Chuck Berry and Muddy Waters which started her life-long passion for rock and blues. She was a classically trained pianist but loved to play rock and played key board and sang in several classic-rock bands. She and her husband traveled the country and the UK fulfilling their passion for rock and blues from the British Invasion bands of the 1960's to today. And they loved the Cleveland music scene. Dr. Houghton also embraced the bold fashion of rock and loved rocking her wardrobe when going out for a night of music with her husband. April 30, 1993 was one of the proudest days of Dr. Houghton's life. That was the day she became a United States Citizen. Dr. Houghton is survived by her husband, Bob Klaus, her daughters, Nicole Houghton and Emma Arledge-Houghton (Rachel), her stepdaughter Stefanie Klaus, her stepson Jared Klaus (Melinda Marksz) and her brother Robert Geeson (Elizabeth). The family asks that, in lieu of flowers, donations be made to St. Jude Children's Research Hospital in Memphis, Tennessee or The Emil Hess Endowed Chair at Southern Research Institute in Birmingham, Alabama to help carry on the life-saving research that is Dr. Janet Houghton's enduring legacy. Or The Rock and Roll Hall of Fame in Cleveland, Ohio. Funeral services will be held 10:00AM, Friday, October 13, 2017 at JOHNSON-ROMITO FUNERAL HOME, 99 W. AURORA RD. (RT. 82, ONE MILE WEST OF RT. 8), NORTHFIELD CENTER, OH (330-468-1443) where friends will be received from 9:30AM until service time. Interment will follow at Markillie Cemetery, Hudson, OH. Friends are then welcome at the family residence, 7415 Valerie Lane, Hudson, OH 44236 from 1:00PM until 8:00PM Friday. www.johnsonromito.com
Published in The Plain Dealer from Oct. 9 to Oct. 11, 2017
BurialMarkillie Cemetery, Hudson, OH, USA
BiographyJanet A. Houghton, Ph.D. to direct the Department of Cancer Biology

Dr. Janet A. Houghton, a leader in the field of cancer research and treatment, has been selected as the new Chair of the Department of Cancer Biology at LRI. Dr. Houghton is currently a Member of the Department of Hematology-Oncology at St. Jude Children’s Research Hospital in Memphis, Tennessee where she has spent much of her scientific career. Dr. Houghton will assume her new position at LRI on October 23, 2006.
Dr. Houghton received her Ph.D. from the University of London’s Institute of Cancer Research in Surrey, England. She then spent nearly 30 years at St. Jude Children’s Research Hospital, quickly moving through the ranks of Postdoctoral Fellow, Research Associate, Assistant Member and Associate Member to full Member. She has published more than 129 original articles on human tumor xenograft models, experimental therapeutics, drug resistance, solid tumors, colon carcinoma and rhabdomyosarcoma as specific human diseases, regulation of drug-induced cell death or apoptosis, oncogenes and apoptosis, Fas-induced apoptosis in solid tumors, and signaling and regulation of death receptors. Dr. Houghton is on the Editorial Board of the International Journal of Oncology and is Senior Editor for Cancer Research. She also serves on several study sections and review boards.
Currently, Dr. Houghton’s research program is focused on understanding the role of death receptors of the TNF receptor superfamily and their signaling pathways in drug-induced apoptosis in solid tumors. The long term goal of her work is to manipulate apoptotic pathways to selectively destroy cancer cells and thus improve clinical outcomes.
It is clear that Dr. Houghton’s passion for science will lead to a great vision for our Department and that her talent for science will help it become reality.
Taken from Cancer Bio Clips, Volume 4, Issue 2, August 2006.4
ResearchAmerican Men & Women of Science. A biographical directory of today's leaders in physical, biological and related sciences. 18th edition, 1992-1993. Eight volumes. New Providence, NJ: R.R. Bowker, 1992. (AmMWSc 18)
American Men & Women of Science(TM) (Bowker(R)). A biographical directory of today's leaders in physical, biological and related sciences. 19th edition. Eight volumes. New Providence, NJ: R.R. Bowker, 1994. (AmMWSc 19)
American Men & Women of Science(TM) (Bowker(R)). A biographical directory of today's leaders in physical, biological and related sciences. 20th edition. Eight volumes. New Providence, NJ: R.R. Bowker, 1998. (AmMWSc 20)
American Men & Women of Science. A biographical directory of today's leaders in physical, biological and related sciences. 21st edition. Eight volumes. Detroit: Gale Group, 2003. (AmMWSc 21)
Who's Who in Frontier Science and Technology. First edition, 1984- 1985. Chicago: Marquis Who's Who, 1984. (WhoFrS)
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://www.stjude.org/departments/houghton_j.htm
  2. [S882] Ancestry.Com, online www.ancestry.com, Biography and Genealogy Master Index (BGMI): Houghton Surname.
  3. [S654] Electronic Web Site, , Columbia University Libraries Online Catalog: Houghton Surname search, Nov. 2003.
  4. [S654] Electronic Web Site, , http://www.lerner.ccf.org/cancerbio/news/2006_houghton.php

Elmer J. Hart1

M, #63552, b. circa 1870

Family: Allie Winn b. c 1870

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
Birthcirca 1870MI, USA, age 10 in 1880 census; age 22 in 1892
MarriageDec 21, 1892Columbus, St. Clair Co., MI, USA1
Pedigree

Citations

  1. [S654] Electronic Web Site, , St. Clair County MI marriages, 1887-1898.
  2. [S1060] Unknown author, St. Clair Co. MI Biog. Memoirs, p. 498.

Allie Winn1

F, #63553, b. circa 1870

Family: Elmer J. Hart b. c 1870

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
Birthcirca 1870age 22 in 1892
MarriageDec 21, 1892Columbus, St. Clair Co., MI, USA1
ParentsDJames Winn and Mary Ainsworth
Pedigree

Citations

  1. [S654] Electronic Web Site, , St. Clair County MI marriages, 1887-1898.
  2. [S1060] Unknown author, St. Clair Co. MI Biog. Memoirs, p. 498.

Raymond Steton Houghton1

M, #63554, b. 16 February 1944, d. 29 February 2008

Family: Mary Patricia Goodrich b. 13 Sep 1945

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthFeb 16, 1944Lewiston, ME, USA, Obit: South Paris, ME3
MarriageAug 11, 1972Memphis, TN, USA, First Presbyterian Church1
DeathFeb 29, 2008Roswell, GA, USA2
ObituaryMar 2, 2008Atlanta, Fulton Co., GA, USA, Atlanta Journal-Constitution, The (GA) - March 2, 2008
Deceased Name: Raymond HOUGHTON
HOUGHTON, Raymond S. Ray Houghton of Roswell, beloved husband, father, son and brother, passed away on February 29, 2008. He was born and raised in South Paris, Maine, moving with his family to Thomasville, Georgia, in 1956. He was a graduate of Thomasville High School and Valdosta State College and was a realtor with Metro Brokers in Roswell for many years. He is survived by his wife of 35 years, Patty; his children Paul, David and Kathryn; his mother, Marion Houghton of Norway, Maine; his sister Rae Jean Gryzmala, of Gray, Maine; and his brother, John Houghton, of Marina del Rey, California. A memorial service will be held at the Roswell Presbyterian Church at 3:00 PM Monday, March 3. The family will receive visitors at a reception following the service. In lieu of flowers the family requests donations to the Roswell Presbyterian Church Stephen Ministry, 755 Mimosa Blvd., Roswell, Georgia 30075. Arrangements by Cremation Society of the South Marietta 770-420-5557.2
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fond.htm
  2. [S654] Electronic Web Site, , http://www.genealogybank.com/gbnk/obituaries; Houghton Surname.
  3. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fondren/… Descendants of Dave and Annie Fondren.

Mary Patricia Goodrich1

F, #63555, b. 13 September 1945

Family: Raymond Steton Houghton b. 16 Feb 1944, d. 29 Feb 2008

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthSep 13, 1945Vicksburg, MS, USA2
MarriageAug 11, 1972Memphis, TN, USA, First Presbyterian Church1
Living2008Roswell, GA, USA
ParentsDMartha Ann Givens b. 1924 d. 29 Jun 1986 m. John Wright Goodrich b. 1925
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fond.htm
  2. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fondren/… Descendants of Dave and Annie Fondren.

Paul Goodrich Houghton1

M, #63556, b. 7 September 1976

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthSep 7, 1976Atlanta, Fulton Co., GA, USA2
Living2008
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fond.htm
  2. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fondren/… Descendants of Dave and Annie Fondren.

David Raymond Houghton1

M, #63557, b. 9 July 1979

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthJul 9, 1979Selma, AL, USA2
Living2008
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fond.htm
  2. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fondren/… Descendants of Dave and Annie Fondren.

Katheryn Patricia Houghton1

F, #63558, b. 6 August 1982

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthAug 6, 1982Atlanta, Fulton Co., GA, USA2
Living2008
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fond.htm
  2. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~rmckibben/fondren/… Descendants of Dave and Annie Fondren.

Mary Houghton1

F, #63559, b. circa 1725, d. 1785

Family 1: Richard Clayton d. 1770

Family 2: Harman Yerkes b. 18 Jan 1719/20, d. 29 Nov 1804

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
Birthcirca 1725CJV opinion
Marriage1
ResidenceSep, 1773Newbritten, Bucks Co., PA, USA
MarriageSep 30, 1773Southampton Baptist Church, Southampton, Bucks Co., PA, USA, Pennsylvania Marriage Records. Harrisburg, PA: Pennsylvania Archives Printed Series, 1876. Series 2, Series 6, page 322. "1773, Sep. 23. Yerkus, Herman, and Mary Clayton"1
WillMay 10, 1784Bucks Co., PA, USA, Pennsylvania, Wills and Probate Records, 1683-1993: Bucks Co., 980 - Page 362.
Mary Yerkes, wife of Harman Yerkes of Warminster late Mary Clayton. Dated 5—10—1784.     Prvd, 2-1-1785. Brother Joseph Houghton and Isaac Hough, Jr.
Joseph Houghton & John Knowled third party to Tripartite Agreement. Richard Houghton son of Bro. Joseph-Elizabeth and Mery Daughters of Bro. Joseph. Niece Elizabeth, wife of Isaac Hough, Jr. Niece Sarah Vanhorne and Niece Jane Linsey Daughter of sister Dinah Dec'd. Friend Isaac Hough, Sr. - Nephew John Houghton, dec'd. Wits: Herman Yerkes, Mary Yerkes, William Vanhorne.
Death1785Bucks Co., PA, USA1
ResearchBucks Co., PA, USA
Nephew/Niece
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~vsummers/…

Richard Clayton1

M, #63560, d. 1770

Family: Mary Houghton b. c 1725, d. 1785

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
Marriage1
Death17701
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~vsummers/…

Harman Yerkes1

M, #63561, b. 18 January 1719/20, d. 29 November 1804

Family: Mary Houghton b. c 1725, d. 1785

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthJan 18, 1719/20Montgomery Co., PA, USA1
MarriageSep 30, 1773Southampton Baptist Church, Southampton, Bucks Co., PA, USA, Pennsylvania Marriage Records. Harrisburg, PA: Pennsylvania Archives Printed Series, 1876. Series 2, Series 6, page 322. "1773, Sep. 23. Yerkus, Herman, and Mary Clayton"1
Research1790PA, USA, slaves
DeathNov 29, 1804Moreland, Montgomery Co., PA, USA1
BiographyHARMAN, YERKES (HERMAN2, ANTHONY1) was born January 18, 1719/20 in Montgomery Co., PA, and died November 29, 1804. He married (1) MARY STROUD March 22, 1749/50, daughter of EDWARD STROUD. He married (2) MARY HOUGHTON September 23, 1773. He married (3) ELIZABETH A BALL March 28, 1788 in First Presbyterian Church, Philadelphia, PA. She died 1819.

Notes for HARMAN YERKES:
Listed in the DAR Patriot Index... as Private from PA.

Harman Yerkes was the fourth son and fifth child of Herman Yerkes by his wife, Elizabeth Watts; born in the Manor of Moreland 18 January 1720; died there 29 November 1804.

He began his business career as a farmer and miller. From 1752 until 1755, he engaged in mercantile pursuits at Plymouth, but
returned to farming the latter year and continued there until 1788. He was a large land owner. His first real estate purchase was made when he was but 26 years old and consisted of a tract of 137 acres, located in Plymouth Township, which he bought 18 May 1747 from his brother, John, paying him 297 pounds. It is believed that he moved to the land purchased about the time he acquired it and that he continued there until about 1762 when he is supposed to have become a resident of Warminster, Bucks County, where in 1765 he was an overseer of the poor, and where, in 1772, he purchased a a plantation of 181 acres from Joseph Noble. The tract was situated on the Street Road at what is now Johnsville Station on the Northeast Pennsylvania Railroad, and on this tract Harman Yerkes established the first homestead of the Yerkeses in Bucks County and there some of his descendants have ever since resided. He returned to the Manor of Moreland in 1788 which continued to be his place of residence the remainder of his life.

Mr. Yerkes was an active supporter of the War of Independence, and in 1775 he and his son Edward, who was but 18 years of age, enrolled themselves in the Warminster Company of Associators. On 31 July 1777, he was recommended to the Executive Council by Judge Henry Wynkoop to look after billeting the poor. It is probable that his military service was with the militia only. On more than one occasion, the British troopers from Philadelphia were his unwelcome visitors, and his family was subjected to the actual terrors and trials of grim war. In this connection, Judge Harman Yerkes, of Bucks County, has contributed the following item:

"His wife, Mary Clayton, proved herself worthy of the duty of taking charge of a young family in such times, as is shown by the following incident, which Mr. Leach heard from the lips of one (Stephan Beans, then a small boy) who was present. "The house then occupied by the family stood where the smaller end of the present homestead now stands. It contained a sitting room and kitchen on the first floor, with an out attachment used as quarters for the slaves. The second floor was divided into convenient rooms by plain board partitions. "The battle of "Crooked Billet" fought in 1778, began less than 2 miles away and the retreat, or rather rout, of the Americans drifted directly over the adjacent lands. Some of the most harrowing scenes of that dreadful butchery occurred within sight of the Yerkes homestead.

"The narrator of the story lived at the next place north, on the Street Road, and the men being away at the scene of strife
or in concealing the horses and cattle, he (Beans) accompanied his mother to the Yerkes Place at the first alarm. While the two women and children were in the sitting room, an American soldier hastily ran into the house, coming from the south side, and took refuge under a bed which stood in the northeast corner of the room. He stated that he was being pursued by the enemy and in much alarm asked that his place of hiding be concealed. Mrs. Yerkes told him he would not be safe there but that by going out of the back door he could put the house between him and his pursuers and might reach the next place where there was a large pile of buckwheat straw, in which he could hide. He obeyed her directions and in a very short time four British soldiers came in the opposite door and inquired for him. The ladies protested that he was not there. The soldiers then looked under the bed, searched the upstairs rooms and, after maliciously sticking their bayonets through the bed clothing, continued the pursuit.

"The American afterwards returned and thanked the ladies for his deliverance and stated that the British had trampled over the straw and thrust their bayonets far into it but fortunately without hitting him. They spoke of setting fire to it but, owing to some alarm, abandoned the idea and departed."

The religious affiliations of Harman Yerkes were matters of some interest to his descendants. His earliest church connection was probably either with the Low Dutch Church, in which faith his father was no doubt born, or with the Baptists, the faith of his mother, but on the eve of his first marriage he identified himself with the Society of Friends, his first wife being of that persuasion. After this his speech and manners are said to have conformed to the custom of the Friends; nevertheless, his second and third marriages were performed by Baptist clergymen, and he seems to have become a member of the Southampton Baptist Church, Bucks County, as he was one of the committee of that church, in 1772, for the building of a new meeting house. He was buried in the graveyard of the same. These latter facts suggest the strong probability that shorty before his second marriage he attached himself to the faith of his mother, and of his distinguished grandfather, the Reverend John Watts.

His death was recorded in the American Daily Advertiser on the date of 07 December 1804.

He married (1) Mary Stroud, daughter of Edward Stroud of Whitemarsh, at Plymouth Meeting House. She died circa 1771 and he
married (2) Mrs. Mary (Houghton) Clayton, widow of Richard Clayton. She died in 1785 and bequeathed a sum of money to the
Southampton Baptist Church for building a wall around its graveyard. She was actively identified with this church whose
pastor, Reverend Jonathan Blackwood married Mary Stroud and Harman Yerkes. He married (3) On 28 March 1788, he married Mrs. Elizabeth (Ball) Tompkins, widow of John Tompkins who died in 1819. After this marriage, Mr. Yerkes moved to his wife's home on the Old York Road in Moreland where the "widow" Tompkins kept an inn and store, the management of which now fell to Mr. Yerkes.

The History of Bucks County book states as follows:

HARMAN YERKES, fourth son of Herman and Elizabeth (Watts) Yerkes, was born in Moreland, January 18, 1720, and died there
November 29, 1804. Like his father he was a farmer and miller. He also followed the mercantile business at Plymouth
Montgomery County, in the years 1752 - 55, where he had purchased a tract of land from his brother John in 1747. In 1762, he moved to Warminster township, Bucks County, being the first of the family to make a home in this county. He purchased 181 acres of land near Johnsville, which still remains the property of his descendants. He returned to Moreland in 1788 and died there November 29, 1804. He was an active supporter of the war for independence. His name appears on the list of Associators in Warminster in 1775, and he served on various committees under the committee of safety. His Warminster home witnessed some of the bloody carnage and rout following the battle of Crooked Billet in 1778. As incident is related of an American soldier being saved from slaughter by four British soldiers who were pursuing him, by the strategy of Mrs. Mary Yerkes, the second wife of Harman, who, when the soldier had sought refuge in the house, conducted him to a rear exit and found him a place of concealment in a pile of buckwheat straw in a neighboring field. His pursuers entered the house and made a diligent search for the fugitive, thrusting their bayonets through beds and up the chimney, to the terror of the women and children of the household.

After locating at Plymouth, Mr. Yerkes became enamored of a Quaker lass, Mary, the daughter of Edward Stroud, of White Marsh, and uniting himself with the Society, was married to her by the simple ceremony of the Society March 22, 1750-1. She died in 1771, and he married (second) Mary (Houghton) Clayton, widow of Richard Clayton. His second wife, died in 1785, and he married in 1787 Elizabeth (Ball) Tompkins, widow of John Tompkins, of Moreland. She was the proprietress of an inn on the Old York road, and his remaining years were spent as "mine host" at this old hostelry. His widow died in 1819.

Notes for MARY STROUD: Of Moreland.

He married (i), at Plymouth Meeting-House, 22 March, 1750-51, Mary, daughter of Edward Stroud, of Whitemarsh. She died circa 1771, and he married (2), 30 September, 1773, Mrs. Mary (Houghton) Clayton, widow of Richard Clayton. She died in 1785, and bequeathed a sum of money to the Southampton Baptist Church for building a wall around its graveyard, with which church she was actively identified, and by whose pastor, Reverend Jonathan Blackwood, she was married to Mr. Yerkes. He married (3), 28 March, 1788, Mrs. Elizabeth (Ball) Tompkins, widow of John Tompkins. She died in 1819.1
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~vsummers/…

Frank Houghton1

M, #63562

Family: Elizabeth Craig b. c 1872

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
Marriage1
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~moyer/dat75.htm#2

Elizabeth Craig1

F, #63563, b. circa 1872

Family: Frank Houghton

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
Birthcirca 1872Philadephia, PA, USA1
Marriage1
ParentsDAndrew Brown Craig and Mary Anne Kearney1
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~moyer/dat75.htm#2

Edith Houghton1

F, #63564

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
Birth
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~moyer/dat75.htm#2

Frank Houghton1

M, #63565

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
Birth
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/~moyer/dat75.htm#2

Robert Henry Standifer1

M, #63566

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
Birth
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/%7Ebbivona, June 12 2002.

Valina Malvina Standifer1

F, #63567

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
Birth
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/%7Ebbivona, June 12 2002.

Laura Elizabeth Milam1

F, #63568, b. 23 January 1860, d. 19 July 1936

Family: Andrew Jackson Hooten b. 25 Feb 1851

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthJan 23, 1860AL, USA1
Marriage1
DeathJul 19, 19361
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/%7ecmsbill/gt.gif

Joseph Cornelius Hooten1

M, #63569, b. 3 October 1877, d. 1881

Biography

Corresponded with authorN
A Contributor to Houghton Surname ProjectN
BirthOct 3, 18771
Death18811
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/%7ecmsbill/gt.gif

Martha Susan Hooten1

F, #63570, b. 14 December 1879

Family: Eugene Gray

  • Marriage*: Martha Susan Hooten married Eugene Gray on 1903.1

Biography

A Contributor to Houghton Surname ProjectN
Corresponded with authorN
BirthDec 14, 1879TX, USA1
Marriage19031
Pedigree

Citations

  1. [S654] Electronic Web Site, , http://freepages.genealogy.rootsweb.com/%7ecmsbill/gt.gif